Tg(Slc5a2-cre)#Tka
Transgene Detail

Summary

• Symbol: Tg(Slc5a2-cre)#Tka
• Name: transgene insertion, Takashi Kadowaki
• MGI ID: MGI:6115244
• Synonyms: SGLT2-cre
• Transgene: Tg(Slc5a2-cre)#Tka Location: unknown
• Alliance: Tg(Slc5a2-cre)#Tka page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Slc5a2-cre)#Tka expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc5a2 (MGI:2181411)

• Mutation details: The construct consisting of a mouse genomic fragment of Slc5a2 including the promoter region, exon 1, intron 1, and the first part of exon 2 from the RP24-178K1 BAC clone followed by cre recombinase, rabbit b-globin and a polyadenylation sequence was used to generate mice. The linearized construct was injected into the pronuclei of fertilized C57BL/6J embryos. Founder information and line numbers were not available. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:245081)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc5a2 (mouse) Summary of all recombinase alleles driven by Slc5a2. Comparative matrix view of recombinase activities Alliance mouse Slc5a2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:245081 Sasaki M, et al., Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney. Diabetes. 2017 Sep;66(9):2339-2350
• All: 1 reference(s)