Zc3h12a^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Zc3h12a^{tm1c(EUCOMM)Hmgu}
• Name: zinc finger CCCH type containing 12A; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6115370
• Synonyms: Mcpip1^flox
• Gene: Zc3h12a Location: Chr4:125012216-125021633 bp, - strand Genetic Position: Chr4, 58.1 cM
• Alliance: Zc3h12a^{tm1c(EUCOMM)Hmgu} page
• IMPC: Zc3h12a gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255787
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt2 cassette was inserted at position 125015788 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 125016657. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). (J:255787)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zc3h12a Mutation: 35 strains or lines available

References

• Original: J:255787 Li Y, et al., Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury. Signal Transduct Target Ther. 2017;2:17066
• All: 9 reference(s)