Abcb11^{tm2(EGFP/cre/ERT2)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Abcb11^{tm2(EGFP/cre/ERT2)Wtsi}
• Name: ATP-binding cassette, sub-family B member 11; targeted mutation 2, Wellcome Trust Sanger Institute
• MGI ID: MGI:6115590
• Synonyms: Abcb11^{tm2(EGFP_CreERT2)Wtsi}
• Gene: Abcb11 Location: Chr2:69068626-69172958 bp, - strand Genetic Position: Chr2, 39.69 cM
• Alliance: Abcb11^{tm2(EGFP/cre/ERT2)Wtsi} page

Mutation origin

• Mutant Cell Line: CEPD0083_1_C11
• Germline Transmission: Earliest citation of germline transmission: J:188991
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMMTOOLS

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Abcb11^{tm2(EGFP/cre/ERT2)Wtsi} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Abcb11 (MGI:1351619)

• Mutation details: According to the construct image presented by The International Mouse Knockout Consortium this allele has a single FRT site, an engrailed 2 splice acceptor site, an EGFP-cre/ERT2 cassette and a neomycin selection cassette that is driven by an autonomous promoter all inserted in the intron between exons 2 and 3 and one loxP sequence inserted in the intron between exons 3 and 4. (J:188991)
• Inheritance: Not Specified

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Abcb11 (mouse) Summary of all recombinase alleles driven by Abcb11. Alliance mouse Abcb11 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcb11 Mutation: 95 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 1 reference(s)