Fdxr^tm1Xch
Targeted Allele Detail

Summary

• Symbol: Fdxr^tm1Xch
• Name: ferredoxin reductase; targeted mutation 1, Xinbin Chen
• MGI ID: MGI:6115883
• Synonyms: Fdxr^-
• Gene: Fdxr Location: Chr11:115158850-115167876 bp, - strand Genetic Position: Chr11, 80.84 cM, cytoband E2
• Alliance: Fdxr^tm1Xch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244082
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.1 kb genomic fragment including exons 1-12 of the Fdxr gene was replaced by lacZ-poly(A) and hUbDpro-neo-poly(A) cassettes through homologous recombination. (J:244082)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fdxr^tm1Xch

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fdxr Mutation: 22 strains or lines available

References

• Original: J:244082 Zhang Y, et al., Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2. Genes Dev. 2017 Jun 15;31(12):1243-56
• All: 3 reference(s)