Cimap3^tm2.1Heli
Targeted Allele Detail

Summary

• Symbol: Cimap3^tm2.1Heli
• Name: ciliary microtubule associated protein 3; targeted mutation 2.1, Heiko Lickert
• MGI ID: MGI:6116222
• Synonyms: Pifo^flox
• Gene: Cimap3 Location: Chr3:105904273-105921962 bp, - strand Genetic Position: Chr3, 46.47 cM, cytoband F3
• Alliance: Cimap3^tm2.1Heli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244372
• Parent Cell Line: IDG3.2 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the selection cassette and left exons 3 through 6 floxed. (J:244372)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cimap3 Mutation: 14 strains or lines available

References

• Original: J:244372 Jung B, et al., Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation. PLoS One. 2016;11(2):e0149477
• All: 1 reference(s)