Tg(Plp1-Eif2ak3*)18Pop
Transgene Detail

Summary

• Symbol: Tg(Plp1-Eif2ak3*)18Pop
• Name: transgene insertion 18, Brian Popko
• MGI ID: MGI:6116281
• Synonyms: PLP/Fv2E-PERK
• Transgene: Tg(Plp1-Eif2ak3*)18Pop Location: unknown
• Alliance: Tg(Plp1-Eif2ak3*)18Pop page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: tacrolimus
• Mutation: Insertion
• Tg(Plp1-Eif2ak3*)18Pop expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Eif2ak3

• Mutation details: This transgene consists of 2.4 kb of the 5' flanking DNA, exon 1, and intron 1 of the mouse proteolipid protein driving oligodendrocyte-specific expression of the Eif2alpha kinase effector domain of Eif2ak3 fused to a polypeptide containing two modified FK506 binding domains. The activity of the kinase is dependent on the FK506 dimerizing agent AP20187. RT-PCR and Western blot confirmed the expression of mRNA and protein in the CNS and oligodendrocytes, respectively. Seven lines were established. (J:238042)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:238042 Lin W, et al., Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis. J Neurosci. 2013 Apr 03;33(14):5980-91
• All: 3 reference(s)