Adgrg7^tm1Wfro
Targeted Allele Detail

Summary

• Symbol: Adgrg7^tm1Wfro
• Name: adhesion G protein-coupled receptor G7; targeted mutation 1, Wei-Fang Rong
• MGI ID: MGI:6116519
• Synonyms: Gpr128^-
• Gene: Adgrg7 Location: Chr16:56544972-56616218 bp, - strand Genetic Position: Chr16, 34.22 cM
• Alliance: Adgrg7^tm1Wfro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243849
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment (8.4 kb) covering exons 10-12 was replaced with a 1.9-kb phosphoglycerate kinase-neomycin resistance (PGK-Neo) cassette. This mutation causes an reading frame shift and thereby generates a loss-of-function allele. Semi-quantitative RT-PCR and immunofluorescence staining confirmed absence of expression in the intestine of homozygous mutant mice. (J:243849)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgrg7 Mutation: 59 strains or lines available

References

• Original: J:243849 Ni YY, et al., Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency. World J Gastroenterol. 2014 Jan 14;20(2):498-508
• All: 1 reference(s)