Frs3^tm1Jheb
Targeted Allele Detail

Summary

• Symbol: Frs3^tm1Jheb
• Name: fibroblast growth factor receptor substrate 3; targeted mutation 1, Jean M Hebert
• MGI ID: MGI:6116679
• Gene: Frs3 Location: Chr17:47999955-48015211 bp, + strand Genetic Position: Chr17, 23.88 cM
• Alliance: Frs3^tm1Jheb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242687
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 3, which encodes the essential phosphotyrosine-binding domain, was replaced with an IRES-LacZ/PGK-neo cassette. Immunoblots confirmed the lack of protein expression from this allele. (J:242687)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Frs3 Mutation: 35 strains or lines available

References

• Original: J:242687 Nandi S, et al., FGF-Dependent, Context-Driven Role for FRS Adapters in the Early Telencephalon. J Neurosci. 2017 Jun 07;37(23):5690-5698
• All: 2 reference(s)