Ccdc62^em1Jxia
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ccdc62^em1Jxia
• Name: coiled-coil domain containing 62; endonuclease-mediated mutation 1, Jun Xia
• MGI ID: MGI:6116688
• Gene: Ccdc62 Location: Chr5:124068683-124107958 bp, + strand Genetic Position: Chr5, 63.28 cM
• Alliance: Ccdc62^em1Jxia page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using four sgRNAs and CRISPR/Cas9 technology in C57BL/6 zygotes to delete exon 2, resulted in the creation of four mutant pups (No.7, 10, 22 and 26). Founder number 7 was used to establish a germ line. This allele represents a 146 bp deletion, which removes most of exon 2 and creates a frame shift and premature stop codon. (J:244081)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccdc62 Mutation: 16 strains or lines available

References

• Original: J:244081 Li Y, et al., A nonsense mutation in Ccdc62 gene is responsible for spermiogenesis defects and male infertility in repro29/repro29 mice. Biol Reprod. 2017 Mar 01;96(3):587-597
• All: 1 reference(s)