Pknox1^tm1.1Rygo
Targeted Allele Detail

Summary

• Symbol: Pknox1^tm1.1Rygo
• Name: Pbx/knotted 1 homeobox; targeted mutation 1.1, Ryo Goitsuka
• MGI ID: MGI:6116700
• Synonyms: PKnox1^fl, Prep1^fl
• Gene: Pknox1 Location: Chr17:31783708-31826667 bp, + strand Genetic Position: Chr17, 16.78 cM, cytoband B-C
• Alliance: Pknox1^tm1.1Rygo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242880
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 was flanked with loxP sites. A FRT-flanked neomycin resistance cassette that was inserted upstream of the first loxP site was removed via Flp-mediated recombination. (J:242880, J:258387)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pknox1 Mutation: 90 strains or lines available

References

• Original: J:242880 Yoshioka K, et al., Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow. PLoS One. 2015;10(8):e0136107
• All: 2 reference(s)