Irf6^tm1Bcsl
Targeted Allele Detail

Summary

• Symbol: Irf6^tm1Bcsl
• Name: interferon regulatory factor 6; targeted mutation 1, Brian C Shutte
• MGI ID: MGI:6116703
• Synonyms: Irf6^fl
• Gene: Irf6 Location: Chr1:192835419-192854331 bp, + strand Genetic Position: Chr1, 97.6 cM
• Alliance: Irf6^tm1Bcsl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242906
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 2 and a loxP-flanked PGK/Neo cassette was inserted in intron 4. Cre-mediated recombination removed the floxed PGK/Neo cassette, leaving exons 3-4 flanked by loxP sites. (J:242906)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irf6 Mutation: 26 strains or lines available

References

• Original: J:242906 Smith AL, et al., Generation and characterization of a conditional allele of Interferon Regulatory Factor 6. Genesis. 2017 Jul;55(7)
• All: 5 reference(s)