Hspb7^tm1.1Yty
Targeted Allele Detail

Summary

• Symbol: Hspb7^tm1.1Yty
• Name: heat shock protein family, member 7 (cardiovascular); targeted mutation 1.1 Yu-Ting Yan
• MGI ID: MGI:6116704
• Synonyms: HspB7 CKO allele, HSPB7^Flox
• Gene: Hspb7 Location: Chr4:141148090-141152621 bp, + strand Genetic Position: Chr4, 74.08 cM, cytoband E1
• Alliance: Hspb7^tm1.1Yty page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246267
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were flanked by loxP sites, and a FLAG-tag sequence was inserted before the stop codon. A FRT-flanked neomycin selection cassette was removed by FLP-mediated recombination. (J:246267)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspb7 Mutation: 14 strains or lines available

References

• Original: J:246267 Juo LY, et al., HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles. J Cell Sci. 2016 Apr 15;129(8):1661-70
• All: 2 reference(s)