Hspb7^tm1.1Chen
Targeted Allele Detail

Summary

• Symbol: Hspb7^tm1.1Chen
• Name: heat shock protein family, member 7 (cardiovascular); targeted mutation 1.1, Ju Chen
• MGI ID: MGI:6116705
• Synonyms: HSPB7^f
• Gene: Hspb7 Location: Chr4:141148090-141152621 bp, + strand Genetic Position: Chr4, 74.08 cM, cytoband E1
• Alliance: Hspb7^tm1.1Chen page

General and heart phenotype of Hspb7^tm1.1Chen/Hspb7^tm1.1Chen Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256653
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 2 of the gene was flanked by two LoxP sites, and an FRT-flanked neomycin cassette was inserted immediately downstream in intron 2. The neomycin cassette was removed in the germline by FLP-mediated recombination. (J:256653)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspb7 Mutation: 14 strains or lines available

References

• Original: J:256653 Wu T, et al., HSPB7 is indispensable for heart development by modulating actin filament assembly. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11956-11961
• All: 1 reference(s)