Hspb7^tm1.2Chen
Targeted Allele Detail

Summary

• Symbol: Hspb7^tm1.2Chen
• Name: heat shock protein family, member 7 (cardiovascular); targeted mutation 1.2, Ju Chen
• MGI ID: MGI:6116706
• Synonyms: HSPB7^-
• Gene: Hspb7 Location: Chr4:141148090-141152621 bp, + strand Genetic Position: Chr4, 74.08 cM, cytoband E1
• Alliance: Hspb7^tm1.2Chen page

General phenotype of Hspb7^tm1.2Chen/Hspb7^tm1.2Chen mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256653
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Intragenic deletion Mutation details: Exon 2 of the gene was flanked by two LoxP sites. Cre-mediated recombination in the germline resulted in the deletion of exon 2. Western blot analysis confirmed the complete absence of protein expression in the hearts of E11.5 homozygous mutant embryos. (J:256653)

Generation of the Hspb7^tm1.1Chen and Hspb7^tm1.2Chen alleles

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspb7 Mutation: 14 strains or lines available

References

• Original: J:256653 Wu T, et al., HSPB7 is indispensable for heart development by modulating actin filament assembly. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11956-11961
• All: 1 reference(s)