Rimbp2^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Rimbp2^tm1.2Geno
• Name: RIMS binding protein 2; targeted mutation 1.2, Genoway
• MGI ID: MGI:6116836
• Gene: Rimbp2 Location: Chr5:128834855-129030550 bp, - strand Genetic Position: Chr5, 67.91 cM
• Alliance: Rimbp2^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238503
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LoxP site was inserted into intron 16 and an FRT-flanked neomycin resistance cassette and a second loxP site into intron 17. The neo cassette was removed through flp-mediated recombination and exon 17 was deleted through cre-mediated recombination. Immunoblot analysis and immunostaining of hippocampal cryosections confirmed absence of protein expression from this allele. (J:238503)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rimbp2 Mutation: 49 strains or lines available

References

• Original: J:238503 Grauel MK, et al., RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11615-11620
• All: 3 reference(s)