Cd99l2^tm1.1Dvst
Targeted Allele Detail

Summary

• Symbol: Cd99l2^tm1.1Dvst
• Name: CD99 antigen-like 2; targeted mutation 1.1, Dietmar Vestweber
• MGI ID: MGI:6116872
• Synonyms: CD99L2^fl
• Gene: Cd99l2 Location: ChrX:70463666-70536455 bp, - strand Genetic Position: ChrX, 36.82 cM
• Alliance: Cd99l2^tm1.1Dvst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193021
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A PGK-neo cassette flanked by FRT sites was inserted downstream of the ATG-containing exon 1, and the cassette and exon 1 were flanked by loxP sites. Flp-mediated recombination removed the PGK-neo cassette leaving exon 1 floxed. (J:193021)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Cd99l2^tm1.1Dvst/Cd99l2^tm1.1Dvst Tg(Tek-cre)1Ywa/0	involves: 129S6/SvEvTac * BALB/c * C57BL/6

Phenotypes:

Affected Systems	cn1
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cellular	√
cellular phenotype	N
abnormal cellular extravasation	√
hematopoietic system	√
abnormal cellular extravasation	√
immune system	√
abnormal cellular extravasation	√
decreased susceptibility to type IV hypersensitivity reaction	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd99l2 Mutation: 4 strains or lines available

References

• Original: J:193021 Seelige R, et al., Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo. J Immunol. 2013 Feb 1;190(3):892-6
• All: 2 reference(s)