Cd99l2^tm1.2Dvst
Targeted Allele Detail

Summary

• Symbol: Cd99l2^tm1.2Dvst
• Name: CD99 antigen-like 2; targeted mutation 1.2, Dietmar Vestweber
• MGI ID: MGI:6117037
• Synonyms: CD99L2 Delta
• Gene: Cd99l2 Location: ChrX:70463666-70536455 bp, - strand Genetic Position: ChrX, 36.82 cM
• Alliance: Cd99l2^tm1.2Dvst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193021
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette flanked by FRT sites was inserted downstream of the ATG-containing exon 1, and the cassette and exon 1 were flanked by loxP sites. Flp-mediated recombination removed the PGK-neo cassette and cre-mediated recombination deleted exon 1, creating a null allele. Immunoblots confirmed the lack of protein expression from this allele. (J:193021)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd99l2 Mutation: 3 strains or lines available

References

• Original: J:193021 Seelige R, et al., Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo. J Immunol. 2013 Feb 1;190(3):892-6
• All: 1 reference(s)