Gripap1^tm1Rlh
Targeted Allele Detail

Summary

• Symbol: Gripap1^tm1Rlh
• Name: GRIP1 associated protein 1; targeted mutation 1, Richard L Huganir
• MGI ID: MGI:6117099
• Synonyms: Grasp1 KO
• Gene: Gripap1 Location: ChrX:7656009-7686805 bp, + strand Genetic Position: ChrX, 3.51 cM
• Alliance: Gripap1^tm1Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256043
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene cassette was inserted into exon 6, creating a premature stop codon. Western blot analysis and immunohistochemistry confirmed the absence of intact protein. (J:256043)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gripap1 Mutation: 7 strains or lines available

References

• Original: J:256043 Chiu SL, et al., GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors. Neuron. 2017 Mar 22;93(6):1405-1419.e8
• All: 1 reference(s)