Mirc11^tm1Rdhl
Targeted Allele Detail

Summary

• Symbol: Mirc11^tm1Rdhl
• Name: microRNA cluster 11, including Mir23a through Mir24-2; targeted mutation 1, Richard Dahl
• MGI ID: MGI:6117136
• Synonyms: mirn23a^-
• Gene: Mirc11 Location: Chr8:84935147-84935550 bp Genetic Position: Chr8, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243248
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mirc11^tm1Rdhl involves 3 genes/genome features (Mir23a, Mir27a, Mir24-2) View all
• Mutation details: A floxed neomycin resistance cassette replaced the cluster sequence containing Mir23a, Mir27a and Mir24-2. (J:243248)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc11 Mutation: 2 strains or lines available

References

• Original: J:243248 Kurkewich JL, et al., The mirn23a microRNA cluster antagonizes B cell development. J Leukoc Biol. 2016 Oct;100(4):665-677
• All: 3 reference(s)