Rr45^tm1.1Tshir
Targeted Allele Detail

Summary

• Symbol: Rr45^tm1.1Tshir
• Name: regulatory region 45; targeted mutation 1.1, Toshihiko Shiroishi
• MGI ID: MGI:6117321
• Synonyms: deltaMFCS4, MFCS4^-
• Gene: Rr45 Location: Chr5:29392493-29393491 bp Genetic Position: Chr5, Syntenic
• Alliance: Rr45^tm1.1Tshir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148018
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Rr45^tm1.1Tshir involves 1 genes/genome features (Rnf32) View all
• Mutation details: A neomycin resistance gene cassette replaced 1 kb including the MFCS4 (mammals-fish conserved sequence 4) enhancer of Shh located within intron 8 of Rnf32. (J:148018)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rr45 Mutation: 2 strains or lines available

References

• Original: J:148018 Sagai T, et al., A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings. Development. 2009 May;136(10):1665-74
• All: 4 reference(s)