Pcdh19^tm1Tac
Targeted Allele Detail

Summary

• Symbol: Pcdh19^tm1Tac
• Name: protocadherin 19; targeted mutation 1, Taconic
• MGI ID: MGI:6117336
• Synonyms: Pcdh19^B-geo
• Gene: Pcdh19 Location: ChrX:132483609-132589736 bp, - strand Genetic Position: ChrX, 55.21 cM
• Alliance: Pcdh19^tm1Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256961
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-3 were replaced with a beta-geo cassette via homologous recombination. Absence of expression was confirmed by qPCR of hippocampal cDNA from 2 week old hemizygous mice. Beta-geo expression was detected in multiple brain regions. (J:256961)

Expression

In Mice Carrying this Mutation:

56 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcdh19 Mutation: 7 strains or lines available

References

• Original: J:256961 Pederick DT, et al., Pcdh19 Loss-of-Function Increases Neuronal Migration In Vitro but is Dispensable for Brain Development in Mice. Sci Rep. 2016 May 31;6:26765
• All: 7 reference(s)