Upf3a^tm1.2Wilk
Targeted Allele Detail

Summary

• Symbol: Upf3a^tm1.2Wilk
• Name: UPF3 regulator of nonsense transcripts homolog A (yeast); targeted mutation 1.2, Miles F Wilkinson
• MGI ID: MGI:6117430
• Gene: Upf3a Location: Chr8:13835615-13849193 bp, + strand Genetic Position: Chr8, 6.38 cM, cytoband A2
• Alliance: Upf3a^tm1.2Wilk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234504
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neomycin resistance gene cassette and loxP site were inserted downstream of exon 3. Flpe-mediated recombination removed the neomycin cassette. The floxed exon 3 was deleted via Cre-mediated recombination. (J:234504)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Upf3a Mutation: 22 strains or lines available

References

• Original: J:234504 Shum EY, et al., The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay. Cell. 2016 Apr 7;165(2):382-95
• All: 1 reference(s)