Map3k15^tm1(cre)Stl
Targeted Allele Detail

Summary

• Symbol: Map3k15^tm1(cre)Stl
• Name: mitogen-activated protein kinase kinase kinase 15; targeted mutation 1, Susumu Tonegawa
• MGI ID: MGI:6117443
• Synonyms: CA2 Cre
• Gene: Map3k15 Location: ChrX:158771429-158906347 bp, + strand Genetic Position: ChrX, 73.95 cM
• Alliance: Map3k15^tm1(cre)Stl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255343
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Map3k15^tm1(cre)Stl expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Map3k15 (MGI:2448588)

• Mutation details: The targetting vector consisted of T2A peptide-Cre-rabbit b-globin polyA-FRT-Neo cassette-FRT was inseted into immediately before the stop codon of mouse Map3k15 gene in BAC (RP24-211E22) was electroporated into ES cells. Resistant clones were selected and confirmed for appropriate homologous recombination. Positive clones were confirmed and selected and positive ES cells were injected into blastocysts of BALB/C mice to generate chimeric mice. (J:255343)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Map3k15 (mouse) Summary of all recombinase alleles driven by Map3k15. Alliance mouse Map3k15 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k15 Mutation: 14 strains or lines available

References

• Original: J:255343 Kohara K, et al., Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits. Nat Neurosci. 2014 Feb;17(2):269-79
• All: 3 reference(s)