Tg(Foxp3*-cre,-Thy1)#Xzhou
Transgene Detail

Summary

• Symbol: Tg(Foxp3*-cre,-Thy1)#Xzhou
• Name: transgene insertion, Xuyu Zhou
• MGI ID: MGI:6117456
• Synonyms: Foxp3 delta CNS1-Cre
• Transgene: Tg(Foxp3*-cre,-Thy1)#Xzhou Location: unknown
• Alliance: Tg(Foxp3*-cre,-Thy1)#Xzhou page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Recombinase)
• Mutation: Insertion
• Tg(Foxp3*-cre,-Thy1)#Xzhou expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Foxp3 (MGI:1891436)

• Mutation details: Transgene consists of the hCre-2A-eqFP650-2A-Thy1.1 cDNA fragment inserted immediately downstream of the Foxp3 ATG translational start site by homologous recombination into a 188-kb mouse BAC (from the C57BL/6 genome; clone RP23-143D8) carrying the intact Foxp3 gene was used. The CNS1 enhancer in Foxp3 gene was deleted by another round of homologous recombination. The modified BAC was purified and microinjected into the pronuclei of a (B6xB6D2) F1 mouse fertilized ovum to generate transgenic line of mice. Three founder mice were generated and screened for Thy1.1 and endogenous Foxp3 expression.The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:252233)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxp3 (mouse) Summary of all recombinase alleles driven by Foxp3. Alliance mouse Foxp3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:252233 Zhang Z, et al., Activation and Functional Specialization of Regulatory T Cells Lead to the Generation of Foxp3 Instability. J Immunol. 2017 Apr 01;198(7):2612-2625
• All: 1 reference(s)