Ncr1^m1J
Spontaneous Allele Detail

Summary

• Symbol: Ncr1^m1J
• Name: natural cytotoxicity triggering receptor 1; mutation 1, Jackson
• MGI ID: MGI:6117782
• Synonyms: Ncr1^C14R, ziggy
• Gene: Ncr1 Location: Chr7:4340723-4348163 bp, + strand Genetic Position: Chr7, 2.5 cM
• Alliance: Ncr1^m1J page

Mutation origin

• Strain of Origin: B6.SJL-Ptprc^a Pepc^b/BoyJ

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A T-to-C transition in the 40th nucleotide from the start codon c.40T>C results in a change from cysteine to arginine at amino acid 14 (p.C14R), which is in the signal peptide region and although transcript is found at normal levels the protein is absent from NK cells. (J:257226)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncr1 Mutation: 40 strains or lines available

References

• Original: J:257226 Jang Y, et al., Cutting Edge: Check Your Mice-A Point Mutation in the Ncr1 Locus Identified in CD45.1 Congenic Mice with Consequences in Mouse Susceptibility to Infection. J Immunol. 2018 Mar 15;200(6):1982-1987
• All: 2 reference(s)