Pcgf5^tm1.1Aiwa
Targeted Allele Detail

Summary

• Symbol: Pcgf5^tm1.1Aiwa
• Name: polycomb group ring finger 5; targeted mutation 1.1, Atsushi Iwama
• MGI ID: MGI:6117847
• Synonyms: Pcgf5^fl
• Gene: Pcgf5 Location: Chr19:36325729-36438370 bp, + strand Genetic Position: Chr19, 31.59 cM
• Alliance: Pcgf5^tm1.1Aiwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248956
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2, which contains the first ATG, was flanked by loxP sites. A FRT-flanked neomycin cassette was inserted downstream of exon 2 but before the second loxP site. Flp-mediated recombination removed the neomycin cassette. (J:248956)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcgf5 Mutation: 18 strains or lines available

References

• Original: J:248956 Si S, et al., Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells. PLoS One. 2016;11(5):e0154561
• All: 1 reference(s)