Eif2s3y^em#Asah
Endonuclease-mediated Allele Detail

Summary

• Symbol: Eif2s3y^em#Asah
• Name: eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked; endonuclease-mediated mutation, Hiroshi Asahara
• MGI ID: MGI:6117849
• Gene: Eif2s3y Location: ChrY:1010543-1028847 bp, + strand Genetic Position: ChrY, Syntenic
• Alliance: Eif2s3y^em#Asah page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Frameshift mutations (1-nucleotide and 4-nucleotide deletions) were introduced in exon 1 using TALEN technology. TALEN RNAs were injected into the cytoplasm of pronuclear-stage oocytes. These alleles were found in mosaic form in Mutant 3. (J:244443)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eif2s3y Mutation: 11 strains or lines available

References

• Original: J:244443 Matsubara Y, et al., TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis. Stem Cells Dev. 2015 May 15;24(10):1164-70
• All: 1 reference(s)