Acrbp^tm1Tba
Targeted Allele Detail

Summary

• Symbol: Acrbp^tm1Tba
• Name: proacrosin binding protein; targeted mutation 1, Tadashi Baba
• MGI ID: MGI:6118116
• Synonyms: Acrbp^-
• Gene: Acrbp Location: Chr6:125026890-125040228 bp, + strand Genetic Position: Chr6, 59.17 cM, cytoband F2
• Alliance: Acrbp^tm1Tba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234286
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced the 472-nucleotide protein-coding region of exons 1-4 via homologous recombination. Immunoblot analysis of testicular extracts confirmed absence of both the ~60-kDa precursor (ACRBP-W) and the variant (ACRBP-V5) protein forms, as well as the ~32-kDA ACRBP-C form which is posttranslationally produced from ACRBP-W during spermatogenesis. (J:234286)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acrbp Mutation: 19 strains or lines available

References

• Original: J:234286 Kanemori Y, et al., Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3696-705
• All: 2 reference(s)