Pgrmc2^tm1.1Jjp
Targeted Allele Detail

Summary

• Symbol: Pgrmc2^tm1.1Jjp
• Name: progesterone receptor membrane component 2; targeted mutation 1.1, John J Peluso
• MGI ID: MGI:6118911
• Synonyms: Pgrmc2^fl
• Gene: Pgrmc2 Location: Chr3:41020772-41037443 bp, - strand Genetic Position: Chr3, 19.66 cM, cytoband C
• Alliance: Pgrmc2^tm1.1Jjp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247103
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Exons 2 and 3 were floxed. Flp-mediated recombination removed the selection cassette. (J:247103)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pgrmc2 Mutation: 8 strains or lines available

References

• Original: J:247103 Clark NC, et al., Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence. Endocrinology. 2017 Mar 01;158(3):640-651
• All: 3 reference(s)