Hacd1^tm1Akih
Targeted Allele Detail

Summary

• Symbol: Hacd1^tm1Akih
• Name: 3-hydroxyacyl-CoA dehydratase 1; targeted mutation 1, Akio Kihara
• MGI ID: MGI:6118922
• Gene: Hacd1 Location: Chr2:14031642-14060846 bp, - strand Genetic Position: Chr2, 10.3 cM, cytoband A2
• Alliance: Hacd1^tm1Akih page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247117
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Using recombineering techniques, exon 6, coding for an active site, was replaced with a loxP site flanked neomycin resistance gene cassette. (J:247117)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hacd1 Mutation: 16 strains or lines available

References

• Original: J:247117 Sawai M, et al., The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways. J Biol Chem. 2017 Sep 15;292(37):15538-15551
• All: 1 reference(s)