H2-D1^b-em2Dvs
Endonuclease-mediated Allele Detail

Summary

• Symbol: H2-D1^b-em2Dvs
• Name: histocompatibility 2, D region locus 1; endonuclease-mediated mutation 2, David V Serreze
• MGI ID: MGI:6118958
• Gene: H2-D1 Location: Chr17:35482070-35486473 bp, + strand Genetic Position: Chr17, 18.61 cM
• Alliance: H2-D1^b-em2Dvs page

Mutation origin

• Strain of Origin: NOD/ShiLtDvs

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This CRISPR/Cas9-mediated 16 bp (CCCGGCCTCGAGGAGC) deletion within exon 2 is predicted to cause an early termination codon and was shown by flow cytometry of homozygotes to cause a null allele (J:257229)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2-D1 Mutation: 47 strains or lines available

References

• Original: J:257229 Racine JJ, et al., Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development. Diabetes. 2018 May;67(5):923-935
• All: 1 reference(s)