Tg(HLA-B39/H2-D/B2m)2Dvs
Transgene Detail

Summary

• Symbol: Tg(HLA-B39/H2-D/B2m)2Dvs
• Name: transgene insertion 2, David V Serreze
• MGI ID: MGI:6119476
• Transgene: Tg(HLA-B39/H2-D/B2m)2Dvs Location: unknown
• Alliance: Tg(HLA-B39/H2-D/B2m)2Dvs page

Transgene origin

• Strain of Origin: NOD/ShiLtDvs

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene encodes a human B2-microglubulin (B2M) covalently linked to the MHC class 1, alpha1 and alpha2 binding domains of the human HLA-B*39:06 gene, and the alpha3, cytoplasmic and transmembrane domains of the murine H2-D1^b. (J:257229)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:257229 Racine JJ, et al., Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development. Diabetes. 2018 May;67(5):923-935
• All: 1 reference(s)