Fmnl1^tm1.2Sdb
Targeted Allele Detail

Summary

• Symbol: Fmnl1^tm1.2Sdb
• Name: formin-like 1; targeted mutation 1.2, Scott D Blystone
• MGI ID: MGI:6119535
• Gene: Fmnl1 Location: Chr11:103061933-103089727 bp, + strand Genetic Position: Chr11, 66.71 cM, cytoband D
• Alliance: Fmnl1^tm1.2Sdb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250144
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4-6 were flanked by loxP sites. Beta-galactosidase reporter and neomycin selection cassettes, flanked by FRT sites, were inserted into intron 3. Flp-mediated recombination removed the reporter and selection cassettes. Cre-mediated recombination deleted exons 4-6. (J:250144)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fmnl1 Mutation: 46 strains or lines available

References

• Original: J:250144 Miller MR, et al., Non-canonical activity of the podosomal formin FMNL1gamma supports immune cell migration. J Cell Sci. 2017 May 15;130(10):1730-1739
• All: 1 reference(s)