Actr2^MF5L12
Chemically induced Allele Detail

Summary

• Symbol: Actr2^MF5L12
• Name: actin related protein 2; modifier of Factor 5 Leiden 12
• MGI ID: MGI:6119567
• Synonyms: Actr2^G
• Gene: Actr2 Location: Chr11:20012304-20062913 bp, - strand Genetic Position: Chr11, 12.88 cM
• Alliance: Actr2^MF5L12 page

Mutation origin

• Strain of Origin: B6.129S2-F5^tm2Dgi

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C to G point mutation in exon 7 that results in the amino acid substitution of glycine for arginine at position 258 (R258G). (J:244506)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Actr2 Mutation: 37 strains or lines available

References

• Original: J:244506 Westrick RJ, et al., Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci. Proc Natl Acad Sci U S A. 2017 Sep 05;114(36):9659-9664
• All: 1 reference(s)