Trp63^{tm1.1(cre/ERT2)Jxu}
Targeted Allele Detail

Summary

• Symbol: Trp63^{tm1.1(cre/ERT2)Jxu}
• Name: transformation related protein 63; targeted mutation 2.1, Jianming Xu
• MGI ID: MGI:6119568
• Synonyms: p63-CreERT2
• Gene: Trp63 Location: Chr16:25502513-25710838 bp, + strand Genetic Position: Chr16, 17.37 cM
• Alliance: Trp63^{tm1.1(cre/ERT2)Jxu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249188
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Trp63^{tm1.1(cre/ERT2)Jxu} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Trp63 (MGI:1330810)

• Mutation details: The CreERT2-pA-FRT-Neo-FRT was inserted into exon 4 of the Trp63 gene resulting in an in-frame fusion after 115th a.a. of Trp63 isoform. Male chimeric mice were crossbred with female FLPeR mice to remove to remove the Frt-flanked PGK-neo cassette. (J:249188)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Trp63 (mouse) Summary of all recombinase alleles driven by Trp63. Comparative matrix view of recombinase activities Alliance mouse Trp63 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp63 Mutation: 59 strains or lines available

References

• Original: J:249188 Lee DK, et al., The prostate basal cell (BC) heterogeneity and the p63-positive BC differentiation spectrum in mice. Int J Biol Sci. 2014;10(9):1007-17
• All: 12 reference(s)