Tenm3^em2.1Luo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tenm3^em2.1Luo
• Name: teneurin transmembrane protein 3; endonuclease-mediated mutation 2.1, Liqun Luo
• MGI ID: MGI:6119578
• Synonyms: Ten3^flox
• Gene: Tenm3 Location: Chr8:48680717-49296986 bp, - strand Genetic Position: Chr8, 27.02 cM, cytoband B2
• Alliance: Tenm3^em2.1Luo page

Mutation origin

• Strain of Origin: (C57BL/6 x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 endonuclease mediated genome editing is used to introduce a reversed loxP site to intron 3 and an FRT-flanked PGK-neomycin resistance cassette and reversed loxP site is placed in intron 4. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 4 floxed. (J:257337)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tenm3 Mutation: 225 strains or lines available

References

• Original: J:257337 Berns DS, et al., Teneurin-3 controls topographic circuit assembly in the hippocampus. Nature. 2018 Feb 15;554(7692):328-333
• All: 2 reference(s)