Pdx1^{tm1.1(flpo)Most}
Targeted Allele Detail

Summary

• Symbol: Pdx1^{tm1.1(flpo)Most}
• Name: pancreatic and duodenal homeobox 1; targeted mutation 1.1, Michael C Ostrowski
• MGI ID: MGI:6119579
• Synonyms: PdxFlpO^ki
• Gene: Pdx1 Location: Chr5:147206907-147212658 bp, + strand Genetic Position: Chr5, 86.84 cM
• Alliance: Pdx1^{tm1.1(flpo)Most} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248550
• Parent Cell Line: S1B6 (ES Cell)
• Strain of Origin: 129S1/SvImJ or C57BL/6J

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Pdx1^{tm1.1(flpo)Most} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pdx1 (MGI:102851)

• Mutation details: A Flpo fragment followed by LoxP-Neo-LoxP was inserted by homologous recombination at the start codon of the Pdx1 gene, replacing exon 1. The neo cassette was removed by crossing with cre expressing mice. (J:248550)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pdx1 (mouse) Summary of all recombinase alleles driven by Pdx1. Comparative matrix view of recombinase activities Alliance mouse Pdx1 gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdx1 Mutation: 35 strains or lines available

References

• Original: J:248550 Wu J, et al., Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele. PLoS One. 2017;12(9):e0184984
• All: 3 reference(s)