Fbxo7^{tm1b(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Fbxo7^{tm1b(EUCOMM)Wtsi}
• Name: F-box protein 7; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:6120740
• Gene: Fbxo7 Location: Chr10:85857836-85887737 bp, + strand Genetic Position: Chr10, 41.91 cM
• Alliance: Fbxo7^{tm1b(EUCOMM)Wtsi} page
• IMPC: Fbxo7 gene page

Mutation origin

• Mutant Cell Line: EPD0622_3_D02
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated excision of the parental Fbxo7^{tm1a(EUCOMM)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon 4 leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fbxo7 Mutation: 27 strains or lines available

Notes

In J:272313, mice carrying the Fbxo7^{tm1b(EUCOMM)Wtsi} allele (whereby the critical exon was deleted by Cre recombinase) were generated by treating Fbxo7^{tm1a(EUCOMM)Wtsi} two-cell embryos with cell permeable Cre as reported in J:213544.

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 2 reference(s)