Tg(Il7-EGFP,-icre,-HBEGF,-luc)#Tslr
Transgene Detail

Summary

• Symbol: Tg(Il7-EGFP,-icre,-HBEGF,-luc)#Tslr
• Name: transgene insertion, Thomas Schuler
• MGI ID: MGI:6120866
• Synonyms: IL-7GCDL
• Transgene: Tg(Il7-EGFP,-icre,-HBEGF,-luc)#Tslr Location: unknown
• Alliance: Tg(Il7-EGFP,-icre,-HBEGF,-luc)#Tslr page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Recombinase, Reporter)
• Mutation: Insertion
• Tg(Il7-EGFP,-icre,-HBEGF,-luc)#Tslr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Tg(Il7-EGFP,-icre,-HBEGF,-luc)#Tslr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Il7 (MGI:96561)

• Mutation details: This transgenic allele was generated by inserting a multicistronic cDNA cassette consisting of enhanced green fluorescent protein (EGFP), improved Cre (icre), human diphteria toxin receptor (HBGF) and the click beetle green luciferase 99 (luc) each separated by the P2A peptide sequence into the mouse Il7 locus replacing translation initiation ATG of the gene carried in the BAC clone RP23-446B12. Successfully recombined BAC were purified and injected into the pronuclei of fertilized C57BL/6J oocytes. Two lines were established showing the same pattern of luciferase expression. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:257407)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Il7 (mouse) Summary of all recombinase alleles driven by Il7. Alliance mouse Il7 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:257407 Shalapour S, et al., Commensal microflora and interferon-gamma promote steady-state interleukin-7 production in vivo. Eur J Immunol. 2010 Sep;40(9):2391-400
• All: 2 reference(s)