Strip1^cin
Spontaneous Allele Detail

Summary

• Symbol: Strip1^cin
• Name: striatin interacting protein 1; cinchy
• MGI ID: MGI:6121067
• Gene: Strip1 Location: Chr3:107519848-107539010 bp, - strand Genetic Position: Chr3, 46.83 cM
• Alliance: Strip1^cin page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The mutation is a three nucleotide (CTG) in-frame deletion in exon 16. This mutation is predicted to result in the deletion of a leucine residue in a highly conserved stretch of five leucines (amino acids 537541) of the encoded protein. In vitro studies showed that the mutant protein is unstable and is present at 1% of the control level. (J:251816)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Strip1 Mutation: 42 strains or lines available

References

• Original: J:251816 Bazzi H, et al., STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10928-E10936
• All: 1 reference(s)