Ptmatm1.1Got
Targeted Allele Detail
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Symbol: |
Ptmatm1.1Got |
Name: |
prothymosin alpha; targeted mutation 1.1, Otsuka GEN Research Institute |
MGI ID: |
MGI:6121068 |
Synonyms: |
ProTalpha- |
Gene: |
Ptma Location: Chr1:86454448-86458434 bp, + strand Genetic Position: Chr1, 43.96 cM, cytoband C5
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Alliance: |
Ptmatm1.1Got page
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Germline Transmission: |
Earliest citation of germline transmission:
J:240549
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 2 and a loxP-flanked MC1-neo cassette was inserted downstream of exon 3. Cre-mediated recombination deleted exons 2-3 and the MC1-neo cassette. Real-time RT-PCR analysis revealed significantly reduced mRNA levels in heterozygous hippocampal dentate gyrus and CA1 regions. Western blot analysis of heterozygous brain tissue confirmed a significant reduction in protein levels, with 73.8% of wild-type levels in the olfactory bulb, 32.1% in anterior cingulate cortex, 37.7% in motor cortex, 30.5% in somatosensory cortex, 44.9% in caudate-putamen (striatum), 43.8% in amygdala, 57.8% in hippocampus, and 47.4% in cerebellum.
(J:240549)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ptma Mutation: |
21 strains or lines available
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Original: |
J:240549 Ueda H, et al., Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory functions and neurogenesis. J Neurochem. 2017 Apr;141(1):124-136 |
All: |
1 reference(s) |
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