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Ptmatm1.1Got
Targeted Allele Detail
Summary
Symbol: Ptmatm1.1Got
Name: prothymosin alpha; targeted mutation 1.1, Otsuka GEN Research Institute
MGI ID: MGI:6121068
Synonyms: ProTalpha-
Gene: Ptma  Location: Chr1:86454448-86458434 bp, + strand  Genetic Position: Chr1, 43.96 cM, cytoband C5
Alliance: Ptmatm1.1Got page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:240549
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and a loxP-flanked MC1-neo cassette was inserted downstream of exon 3. Cre-mediated recombination deleted exons 2-3 and the MC1-neo cassette. Real-time RT-PCR analysis revealed significantly reduced mRNA levels in heterozygous hippocampal dentate gyrus and CA1 regions. Western blot analysis of heterozygous brain tissue confirmed a significant reduction in protein levels, with 73.8% of wild-type levels in the olfactory bulb, 32.1% in anterior cingulate cortex, 37.7% in motor cortex, 30.5% in somatosensory cortex, 44.9% in caudate-putamen (striatum), 43.8% in amygdala, 57.8% in hippocampus, and 47.4% in cerebellum. (J:240549)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptma Mutation:  21 strains or lines available
References
Original:  J:240549 Ueda H, et al., Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory functions and neurogenesis. J Neurochem. 2017 Apr;141(1):124-136
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory