Dstyktm1.2Zlh
Targeted Allele Detail
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Symbol: |
Dstyktm1.2Zlh |
Name: |
dual serine/threonine and tyrosine protein kinase; targeted mutation 1.2, Ze-Lan Hu |
MGI ID: |
MGI:6121070 |
Gene: |
Dstyk Location: Chr1:132345293-132394696 bp, + strand Genetic Position: Chr1, 57.24 cM, cytoband E4
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Alliance: |
Dstyktm1.2Zlh page
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Germline Transmission: |
Earliest citation of germline transmission:
J:226871
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: A loxP site was inserted into intron 3 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 13. The neo cassette was removed through subsequent flp-mediated recombination. Exons 4-13 were deleted through subsequent cre-mediated recombination. Exons 8-13 code for the kinase domain. qRT-PCR and western blots confirmed the absence of expression from this allele.
(J:226871)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Dstyk Mutation: |
68 strains or lines available
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Original: |
J:226871 Li K, et al., DSTYK kinase domain ablation impaired the mice capabilities of learning and memory in water maze test. Int J Clin Exp Pathol. 2014;7(10):6486-92 |
All: |
1 reference(s) |
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