Lama3^tm1Arte
Targeted Allele Detail

Summary

• Symbol: Lama3^tm1Arte
• Name: laminin, alpha 3; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:6121104
• Synonyms: Lama3^flox
• Gene: Lama3 Location: Chr18:12466876-12716070 bp, + strand Genetic Position: Chr18, 6.2 cM, cytoband A
• Alliance: Lama3^tm1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240054
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 50-53 were flanked by loxP sites and a FRT-flanked neomycin cassette was inserted upstream of exon 50 after the first loxP site. (J:240054)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lama3 Mutation: 192 strains or lines available

References

• Original: J:240054 Pesch M, et al., Targeted Disruption of the Lama3 Gene in Adult Mice Is Sufficient to Induce Skin Inflammation and Fibrosis. J Invest Dermatol. 2017 Feb;137(2):332-340
• All: 1 reference(s)