Lrch1^em1Hwa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrch1^em1Hwa
• Name: leucine-rich repeats and calponin homology (CH) domain containing 1; endonuclease-mediated mutation 1, Hongyan Wang
• MGI ID: MGI:6121113
• Gene: Lrch1 Location: Chr14:74992115-75185316 bp, - strand Genetic Position: Chr14, 39.39 cM
• Alliance: Lrch1^em1Hwa page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: TALEN technology was used to introduce a 2 nucleotide deletion and a 1 nucleotide insertion in exon 1, creating a premature stop codon that truncates the coding region after 49 amino acids. (J:238772)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrch1 Mutation: 46 strains or lines available

References

• Original: J:238772 Xu X, et al., LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis. J Exp Med. 2017 Jan;214(1):209-226
• All: 2 reference(s)