Mirc34^tm1.1Pisc
Targeted Allele Detail

Summary

• Symbol: Mirc34^tm1.1Pisc
• Name: microRNA cluster 34, including Mir449a through Mir449c; targeted mutation 1.1, Piotr Sicinski
• MGI ID: MGI:6121457
• Gene: Mirc34 Location: Chr13:113172517-113174158 bp Genetic Position: Chr13, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256929
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of the microRNA cluster and a loxP site was inserted downstream of the cluster via homologous recombination. Cre-mediated recombination removed the neo cassette and microRNA cluster. (J:256929)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc34 Mutation: 1 strain or line available

References

• Original: J:256929 Otto T, et al., Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10660-10665
• All: 1 reference(s)