Mir34a^tm1.1Pisc
Targeted Allele Detail

Summary

• Symbol: Mir34a^tm1.1Pisc
• Name: microRNA 34a; targeted mutation 1.1, Piotr Sicinski
• MGI ID: MGI:6121459
• Gene: Mir34a Location: Chr4:150152911-150153012 bp, + strand Genetic Position: Chr4, 80.85 cM
• Alliance: Mir34a^tm1.1Pisc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256929
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of the microRNA and a loxP site was inserted downstream via homologous recombination. Cre-mediated recombination removed the neo cassette and microRNA. (J:256929)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir34a Mutation: 9 strains or lines available

References

• Original: J:256929 Otto T, et al., Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10660-10665
• All: 1 reference(s)