Tg(Aldh1l1-cre/ERT2)02Kan
Transgene Detail

Summary

• Symbol: Tg(Aldh1l1-cre/ERT2)02Kan
• Name: transgene insertion 02, Klaus-Armin Nave
• MGI ID: MGI:6121471
• Synonyms: Aldh1l1-CreERT2
• Transgene: Tg(Aldh1l1-cre/ERT2)02Kan Location: unknown
• Alliance: Tg(Aldh1l1-cre/ERT2)02Kan page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Aldh1l1-cre/ERT2)02Kan expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Aldh1l1 (MGI:1340024)

• Mutation details: The transgene was generated by inserting a cre/ERT2 cassette into intron 1/ exon 2 of the mouse Aldh1l1 in a murine BAC (BAC RP23-7M9) by homologous recombination in bacteria. Pronucleus injection gave rise to 5 transgenic founder mice. Three out of five founder mice that were crossed with reporter mice showed expression in the brain. Only one line (line 02) showed robust expression in forebrain astrocytic cells and minimal expression in other cell types of the brain and was used for further analyses. (J:247456)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aldh1l1 (mouse) Summary of all recombinase alleles driven by Aldh1l1. Comparative matrix view of recombinase activities Alliance mouse Aldh1l1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:247456 Winchenbach J, et al., Inducible targeting of CNS astrocytes in Aldh1l1-CreERT2 BAC transgenic mice. F1000Res. 2016;5:2934
• All: 8 reference(s)