Tg(CD2-Lrch1)#Liux
Transgene Detail

Summary

• Symbol: Tg(CD2-Lrch1)#Liux
• Name: transgene insertion, Xiaolong Liu
• MGI ID: MGI:6121483
• Synonyms: Lrch1 Tg
• Transgene: Tg(CD2-Lrch1)#Liux Location: unknown
• Alliance: Tg(CD2-Lrch1)#Liux page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-Lrch1)#Liux expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lrch1 (MGI:2443390)	Driven by human pomoter

• Mutation details: The transgene construct comprises the human promoter, HA tag sequence and the mouse cDNA. The resulting transgenic allele specifically overexpresses the mouse gene in T and B lymphocytes. Western blots confirmed the expression of the allele in primary T cells. The pound symbol (#) was used because no line is specified. (J:238772)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:238772 Xu X, et al., LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis. J Exp Med. 2017 Jan;214(1):209-226
• All: 2 reference(s)