Gck^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Gck^tm1.1Arte
• Name: glucokinase; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:6140011
• Synonyms: Gck^lox
• Gene: Gck Location: Chr11:5850820-5900081 bp, - strand Genetic Position: Chr11, 3.88 cM
• Alliance: Gck^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247100
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 5 and 6 were flanked by loxP sites and a FRT-flanked positive selection marker puromycin was inserted in intron 4. Flp-mediated recombination removed the puromycin gene. (J:247100)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gck Mutation: 64 strains or lines available

References

• Original: J:247100 Steinbusch LK, et al., Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase. Diabetes. 2016 Oct;65(10):2920-31
• All: 3 reference(s)