Cfap44em1Pfr
Endonuclease-mediated Allele Detail
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Symbol: |
Cfap44em1Pfr |
Name: |
cilia and flagella associated protein 44; endonuclease-mediated mutation 1, Pierre F Ray |
MGI ID: |
MGI:6140014 |
Synonyms: |
Cfap44- |
Gene: |
Cfap44 Location: Chr16:44215159-44302791 bp, + strand Genetic Position: Chr16, 28.72 cM
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Alliance: |
Cfap44em1Pfr page
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Sperm from Cfap44em1Pfr/Cfap44em1Pfr males reveal multiple structural axonemal defects
Show the 3 phenotype image(s) involving this allele.
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Strain of Origin: |
Not Specified
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Allele Type: |
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Endonuclease-mediated (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: CRISPR/Cas9-mediated mutagenesis created a 7 bp insertion (InsTCAGATA) in exon 3. RT-PCR analysis of testis RNA confirmed the production of an abnormal transcript leading to a premature stop codon.
(J:257803)
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Cfap44em1Pfr/Cfap44em1Pfr and Cfap43em1Pfr/Cfap43em1Pfr mice were generated by targeting exon 3 and 21, respectively |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cfap44 Mutation: |
84 strains or lines available
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Original: |
J:257803 Coutton C, et al., Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human. Nat Commun. 2018 Feb 15;9(1):686 |
All: |
3 reference(s) |
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